About the Challenge

The Myelofibrosis (MF) Challenge was started in 2012 as a joint grant program between the MPN Research Foundation and The Leukemia & Lymphoma Society. The program shifted in 2014 when it was broadened and renamed the MPN Challenge Grant program.

For a list of 2012 and 2013 recipients click here.

When the MF Challenge was begun in 2012 our focus was simple: to identify the cause(s) and potential treatments for fibrosis in the bone marrow, the key characteristic of myelofibrosis (MF). We began this program because in spite of the current high level of activity in MPN research, there were important questions that remained unanswered – and the most urgent were those associated with MF, the most virulent of the MPNs.

However, we have realized that much of the research focused on MF overlaps research for PV and ET. In fact, it’s frequently hard to tell where one begins and the other ends. In all cases research is focused on some malfunction in the bone marrow, and discoveries in one area are highly likely to impact all the MPNs. As a result, we are renaming our grant program the 2014 MPN Challenge.

The goal of the 2014 MPN Challenge is to continue to search for the factor(s) that induce(s) fibrosis in bone marrow, and in addition to identify new avenues of research which will strengthen the overall understanding of the cause(s) and potential treatments for all of the MPNs (ET, PV and MF). We also encourage investigators in other fields whose research may have cross-over appeal to the MNP research community.

We are requesting proposals in the following areas:

1. Fibrosis and the Bone MarrowNiche.
2. CALR Mutation.
3. Reducing MPN Allele Burden.
4. Selective JAK2 inhibition.
5. Immunotherapy.

Based on the response to MF Challenge RFPs in 2012 and 2013, MPNRF and LLS are encouraged to believe that ‘paradigm-shifting’ strategies can be identified in many areas of cancer and basic biology research which can be brought to bear in the search for MPN treatments. These new strategies, in combination with currently emerging treatments, could truly change the course of these diseases.

Depending on the response to this RFP (i.e., if multiple proposals of sufficient potential to merit an award are received), we anticipate funding up to 10 awards in calendar year 2014.

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