Ann Mullally 2012

Ann Mullaly & Benjamin L. Ebert, of Brigham & Women’s Hospital will attempt to determine the cytokines that are necessary and sufficient to induce fibrotic transformation in JAK2V617F-mediated MPNs, using an in-vivo model of MF in a JAK2 knockin mouse they have recently developed. The information obtained will provide the basis for development of novel therapeutics for the treatment of MF patients, such as neutralizing antibodies and/or small molecules that inhibit key cytokine drivers of MF.

Ann Mullally has worked with MPN Research Foundation grantee Benjamin Ebert before on his project focused on genome sequencing.

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