Mohi 2013

"JAK2 cooperating factors in myelofibrosis"

This grant llooks at the contribution of two genes to JAK2V617F activity in the MPNs. The genes include SHP2, a protein phosphatase that can both increase and decrease signaling in different contexts, and a transcription regulator named Bmi1. The study is expected to provide new insights into how genes cooperate to promote MPNs.

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