Passegue 2013

"Osteoblasts as drivers of MF"


Dr. Passegué has recently shown that multi-potent stromal cells respond to cytokines secreted by MPN myeloid cells by converting to osteoblastic lineage cells (OBCs) in mouse models of CML. These altered OBCs drive an inflammatory process in the bone that she proposes leads to fibrosis. In this grant, she will study whether a similar phenomenon occurs in the MPNs by using the JAK2V617F and MPLW515L models.

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