Pearlie Epling-Burnette 2012

Pearlie Epling-Burnette and Adam Mailloux, of the H. Lee Moffitt Cancer Center will investigate the linkage between cellular senescence and fibrosis, and specifically whether TGF-Beta-induced senescence in bone marrow-derived mesenchymal stem cells (MSCs) is associated with increased collagen deposition, contributing to fibrosis in patients with MPNs. They will use both in-vitro and in-vivo models to focus specifically on the role of FGF2 secretion by MSCs, which induces senescence of MSCs characterized by decreasing proliferative capacity and increased collagen secretion. An understanding of these mechanisms will provide new therapeutic targets for MF and other fibrotic diseases.

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