Spek 2012

C. Arnold Spek, of the Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam will investigate the role of protease-activated receptors (PARs), the downstream effect of PARs on the coagulation system, and the consequent effect on bone marrow fibrosis in myelofibrosis patients. PARs have been implicated in many other types of fibrosis (e.g., pulmonary fibrosis), but their role and effect in myelofibrosis is not clearly understood. The investigators will study the effect of PARs in novel co-cultured systems of myelofibrosis, which may provide a novel alternative model of disease exploration. Using this model system, they will also begin to test the effects of PAR inhibitors.

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