Varga-Licht 2013

"Adipocytes as drivers of MF"

The PIs propose that adipocytes (fat cells) in the bone marrow respond to altered cytokine secretion in such a way that they increase production of fibroblasts and subsequent fibrosis. They use novel mouse models to study this process. They will also test whether an inhibitor of one pathway that controls adipogenesis can block fibrosis in an animal model. A strength of the grant is the new collaboration between Dr. Varga, who is an expert of pulmonary fibrosis and Dr. Licht who is an expert in hematopoiesis.

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