Verma Zhao 2012

Amit Verma and Zhizhuang Joe Zhao, of the Albert Einstein College of Medicine and University of Oklahoma Health Sciences Center will investigate the role of TGF-Beta as a mediator of fibrosis in primary myelofibrosis. As a first aim, they will determine the mechanisms of constitutive activation of TGF-Beta in bone marrow failure and will identify its downstream effectors, using bone marrow samples from patients with MF. As a second aim, they will assess the effectiveness of a specific TGF-Beta inhibitor on MF in a transgenic mouse model of MF, with the hope of setting the stage for trials of such inhibitors in myelfoibrosis patients.

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