Wang 2013

"Improved mouse model of MF and effects of TPO"


Wang and Hoffman recently showed that blood stem cells from the spleen of MF patients show an increased stem cell activity as compared to stem cells from peripheral blood. Despite showing improved blood cell activity in recipient mice, the mice do not show changes in megakaryocytes or develop myelofibrosis. She proposes to introduce human thrombopoietin (the cytokine that promotes megakaryocytes) into mice that are transplanted with MF splenic stem cells. Wang will also study the requirement for TPO in proliferation of MF cells and the disease in recipient mice. The significance of this proposal is that development of a more faithful mouse model of MF will improve our ability to study the biology of MF in vivo and test novel MF therapies

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